Longitudinal anellome dynamics in the upper respiratory tract of children with acute respiratory tract infections

Abstract Anelloviruses (AVs) are ubiquitous in humans and the most abundant components of commensal virome. Previous studies on diversity, transmission persistence AVs mainly focused blood or transplanted tissues from adults; however, profile anellome respiratory tract children barely known. We investigated their dynamics upper a cohort with acute infections (ARTIs). Different to that adult, betatorquevirus is genus, followed by alphatorquevirus. found relative abundance was higher earlier time points, contrast, alphatorquevirus later points; these results might suggest decreased age increased childhood. No difference regarding diversity between single multiple ARTIs, consistent idea anellovirus not associated certain disease. Most transient small proportion (8%) them were be possible persistent, ranging one month as long 56 months. Furthermore, individual appeared unique dynamic, replacement existing new ones common over different points. These findings demonstrate may early colonizer children, unique, which featured both chronic AV community replacement.